Biomarkers in Drug Design

Technological advancements in the molecular characterization of cancers have assisted researchers to identify an increasing number of key molecular drivers of cancer progression. These drug discoveries have led to multiple novel anticancer therapeutics, and clinical advantage in selected patient populations. Despite this, the identification of clinically relevant predictive biomarkers of response continues to lag behind. In this review, we discuss strategies for the molecular characterization of cancers and the importance of biomarkers for the development of novel antitumor therapeutics.

The discovery and evaluation of any novel biomarkers will ideally be specialised to Clinical Laboratory Improvement Amendments (CLIA) and Good Clinical Laboratory Practice (GCLP) standards, so as to ensure accuracy and reproducibility of laboratory procedures. Predictive biomarkers indicate the likelihood of response to a specific antitumor therapy. Such assays should be scientifically sound, Predictive biomarkers include both tumor-specific and surrogate biomarkers, and are crucial to accelerating the drug development process

  • Biomarker Discovery for Immuno-Oncology Agents
  • Biomarkers in Drug Design & Clinical Trial
  • Dose-Selection Biomarkers
  • Biomarkers of Toxicity & Pharmacology
  • Biomarkers of Efficacy

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